Amyris’s Shake up: A True Housecleaning or Sign It’s Desperate to Partner to Grow Demand?

Just days before its quarterly earnings call this month, Amyris sparked a sell-off of its stock when it announced that President and CEO John Melo would keep his job as three other executives leave: Mario Portela, former President of Global Operations and COO; Tamara Tompkins, former Executive Vice President, General Counsel, and Corporate Secretary; and Neil Renninger, former Chief Technical Officer. We interviewed Neil for Lux’s recent profile of Amyris (Client registration required), just before the announcement of back-peddling on earnings and production targets. Neil will remain a member of Amyris’s Board of Directors, which isn’t a surprise since he was among the original co-founders.

In addition to the departures, several other executives will change positions or join Amyris. Highlights include Peter Boynton, formerly of Tate & Lyle – one of Amyris’s partners – and who’s been with Amyris since late 2009, will now lead business development (See the report, “Solving the Bio-Based Chemicals Partnership Puzzle.” Client registration required.). Paulo Diniz, who has been leading Amyris Brasil, will add strategic partnerships to his responsibilities. Gary Loeb, eleven-year veteran of Genentech before joining Amyris in mid-2011, will take the lead as Amyris General Counsel and Corporate Secretary. Steve Mills brings three decades of experience at ADM to his new role as Chief Financial Officer. Mark Patel shifts from VP of Strategy to Senior VP of Commercial Operations, concerned with products strategy and sales growth. Ramesh Raman was promoted from VP Global Supply Chain Operations to Senior VP of Global Manufacturing, responsible for manufacturing and supply chain.

In light of Amyris’s recent changes in earnings and production guidance, it’s no secret things need to change there. But no evidence of show-stopping technical challenges exists. Given that, a drastic management shake-up is not warranted, if the existing team can accelerate demand growth.

In addition, what’s striking about this “shake-up” is how little it changed things. Minor alterations to titles and “promotions” from VP to Senior VP. The exits of the former COO, CTO, and General Counsel and addition of the ADM veteran CFO reflect housekeeping rather than full house-cleaning on the part of CEO Melo and the Board. Melo retains the Board’s support, taking an approach of scapegoating a few, rather than starting from scratch and reflects no decisive change in strategy – except to focus on growth.

Though Amyris could potentially be the next casualty in the unquestionably harrowing world of bioproduct commercialization, the Board may realize in the face of possible bankruptcy it should allow Melo to focus on growing demand, rather than hiring another management team. Adjusting to more austere times and doing the hard work of increasing demand is the new normal for Amyris, and this may be the best time to invest with an equity stake and partner with Amyris, ever. The question remains, however: Can Amyris build or access sufficient markets to bring in substantial revenue with its farnesene-based platform?

Tate & Lyle and Roquette take synthetic biology further into food, personal care, and agriculture

Not one, not two, but three synthetic biology food-related announcements recently hit the wires in short order. First there was Abunda Nutrition’s debut, and the company’s plan to use synthetic biology to produce ingredients like vanillin and nutritional fats and oils (see the November 2, 2010 LRTJ*) of a contract manufacturing agreement between Tate & Lyle and Amyris to produce farnesene, a set of compounds that includes, among other things, the scent of apples. And topping it off was the report of a joint venture between Roquette and Solazyme to make “oil-, protein-, and fiber-based products aimed at delivering improved performance with a superior health profile compared to ingredients in the market today.” According to the announcement, Roquette will fund and build a jointly owned, commercial-scale manufacturing plant at one of its corn wet mills. The plant’s annual production capacity will be on the order of tens of thousands of tons.

We’ve discussed the entrance of synthetic biology into food before, and these announcements naturally bolster that trend (see the June 29, 2010 LRBJ*). Likewise, we have mentioned the convergence of agriculture, energy, and chemicals in previous posts (see the September 15, 2009 LRBJ*). Adding public announcements to discussions we’ve had with companies in the space, we see an increasing flight in industrial biotech from fuels to other products. It remains to be seen whether those “other products” will be synthetic biology technologies such as these, or algae companies looking to secure revenues while they are at small scale. Either way, synthetic biology is no longer an activity that companies in food, personal care, or agriculture can watch from the sidelines. Like their peers in energy and chemicals already have done, clients in these industries should examine the likes of Amyris, Solazyme, LS9, and Blue Marble as strategic partners for future products.

* Client registration required.